Publications
Publications
In review and/or biorxiv
In review and/or biorxiv
104. Ultra-dilute developability analysis of antibody self-association and non-specific bindings, in review (2024).
104. Ultra-dilute developability analysis of antibody self-association and non-specific bindings, in review (2024).
103. Monoclonal antibody generation using single B-cell screening for treating infectious diseases, in review (2024).
103. Monoclonal antibody generation using single B-cell screening for treating infectious diseases, in review (2024).
102. Human antibody polyreactivity is governed primarily by the heavy chain complementarity-determining regions, in review (2024).
102. Human antibody polyreactivity is governed primarily by the heavy chain complementarity-determining regions, in review (2024).
101. Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils, in review (2024). [link]
101. Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils, in review (2024). [link]
Published or in press
Published or in press
100. Native ion mobility-mass spectrometry reveals the binding mechanisms of anti-amyloid therapeutic antibodies, Protein Sci, in press (2024).
100. Native ion mobility-mass spectrometry reveals the binding mechanisms of anti-amyloid therapeutic antibodies, Protein Sci, in press (2024).
99. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates, Biotechnol Prog (2024). [link]
99. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates, Biotechnol Prog (2024). [link]
98. Reduction of monoclonal antibody viscosity using interpretable machine learning, mAbs (2024). [link]
98. Reduction of monoclonal antibody viscosity using interpretable machine learning, mAbs (2024). [link]
97. Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily, Cell Chem Biol, in press (2024). [link]
97. Facile generation of biepitopic antibodies with intrinsic agonism for activating receptors in the tumor necrosis factor superfamily, Cell Chem Biol, in press (2024). [link]
96. Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs, Cell Chem Biol (2024). [link] [news story]
96. Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs, Cell Chem Biol (2024). [link] [news story]
95. Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates, Front Immunol (2023). [link]
95. Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates, Front Immunol (2023). [link]
94. Optimization of therapeutic antibodies for reduced self-association and non-specific binding using interpretable machine learning, Nat Biomed Eng (2024). [link] [news story]
94. Optimization of therapeutic antibodies for reduced self-association and non-specific binding using interpretable machine learning, Nat Biomed Eng (2024). [link] [news story]
92. Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data, Bioinformatics (2023). [link]
92. Position-Specific Enrichment Ratio Matrix scores predict antibody variant properties from deep sequencing data, Bioinformatics (2023). [link]
91. Computational optimization of antibody humanness and stability by systematic energy-based ranking, Nat Biomed Eng (2023). [link]
91. Computational optimization of antibody humanness and stability by systematic energy-based ranking, Nat Biomed Eng (2023). [link]
90. Characterization of pairs of toxic and nontoxic misfolded protein oligomers elucidates the structural determinants of oligomer toxicity in protein misfolding diseases, Acc Chem Res (2023). [link]
90. Characterization of pairs of toxic and nontoxic misfolded protein oligomers elucidates the structural determinants of oligomer toxicity in protein misfolding diseases, Acc Chem Res (2023). [link]
89. Assessing developability early in the discovery process for novel biologics, mAbs (2023). [link]
89. Assessing developability early in the discovery process for novel biologics, mAbs (2023). [link]
88. Approaches to expand the conventional toolbox for discovery and selection of drug-like antibodies, mAbs (2023). [link]
88. Approaches to expand the conventional toolbox for discovery and selection of drug-like antibodies, mAbs (2023). [link]
87. Unlocking the potential of agonist antibodies for treating cancer using antibody engineering, Trends Mol Med (2023). [link]
87. Unlocking the potential of agonist antibodies for treating cancer using antibody engineering, Trends Mol Med (2023). [link]
85. Reduction of therapeutic antibody self-association using yeast-display selections and machine learning, mAbs (2022). [link] [press release]
85. Reduction of therapeutic antibody self-association using yeast-display selections and machine learning, mAbs (2022). [link] [press release]
84. Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space, Nat Commun (2022). [link] [blog] [press release]
84. Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space, Nat Commun (2022). [link] [blog] [press release]
83. Mutational analysis of SARS-CoV-2 Variants of Concern reveals key tradeoffs between receptor affinity and antibody escape, PLOS Comput Biol (2022). [link]
83. Mutational analysis of SARS-CoV-2 Variants of Concern reveals key tradeoffs between receptor affinity and antibody escape, PLOS Comput Biol (2022). [link]
82. Isolating anti-amyloid antibodies from yeast-displayed libraries, Methods Mol Biol (2022). [link]
82. Isolating anti-amyloid antibodies from yeast-displayed libraries, Methods Mol Biol (2022). [link]
81. Rapid and quantitative in-vitro evaluation of SARS-CoV-2 neutralizing antibodies and nanobodies, Anal Chem (2022). [link]
81. Rapid and quantitative in-vitro evaluation of SARS-CoV-2 neutralizing antibodies and nanobodies, Anal Chem (2022). [link]
80. Antibodies with weakly basic isoelectric points minimize trade-offs between formulation and physiological colloidal properties, Mol Pharm (2022). [link]
80. Antibodies with weakly basic isoelectric points minimize trade-offs between formulation and physiological colloidal properties, Mol Pharm (2022). [link]
79. Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis, STAR Protoc (2022). [link]
79. Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesis, STAR Protoc (2022). [link]
77. Agonist antibody discovery: experimental, computational and rational engineering approaches, Drug Discov Today (2022). [link]
77. Agonist antibody discovery: experimental, computational and rational engineering approaches, Drug Discov Today (2022). [link]
76. A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain, PLoS One (2021). [link]
76. A hybridoma-derived monoclonal antibody with high homology to the aberrant myeloma light chain, PLoS One (2021). [link]
75. Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening, Sci Rep (2021). [link]
75. Discovery and characterization of high-affinity, potent SARS-CoV-2 neutralizing antibodies via single B cell screening, Sci Rep (2021). [link]
74. Systematic engineering of optimized autonomous heavy-chain variable domains, J Mol Biol (2021). [link]
74. Systematic engineering of optimized autonomous heavy-chain variable domains, J Mol Biol (2021). [link]
73. Engineered multivalent nanobodies potently and broadly neutralize SARS-CoV-2 variants, Adv Ther (2021). [link]
73. Engineered multivalent nanobodies potently and broadly neutralize SARS-CoV-2 variants, Adv Ther (2021). [link]
72. Highly sensitive detection of antibody non-specific interactions using flow cytometry, mAbs (2021). [link]
72. Highly sensitive detection of antibody non-specific interactions using flow cytometry, mAbs (2021). [link]
71. Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods, mAbs (2021). [link]
71. Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods, mAbs (2021). [link]
70. Ultra-dilute measurements of self-association for the identification of antibodies with favorable high concentration solution properties, Mol Pharm (2021). [link]
70. Ultra-dilute measurements of self-association for the identification of antibodies with favorable high concentration solution properties, Mol Pharm (2021). [link]
69. Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis, Cell Chem Biol (2021). [link][news story]
69. Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesis, Cell Chem Biol (2021). [link][news story]
68. Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity, J Biol Chem (2021). [link]
68. Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity, J Biol Chem (2021). [link]
67. Directed evolution of conformation-specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations, Biotech Biogen (2021). [link]
67. Directed evolution of conformation-specific antibodies for sensitive detection of polypeptide aggregates in therapeutic drug formulations, Biotech Biogen (2021). [link]
66. Toward in silico CMC: An industrial collaborative approach to model‐based process development, Biotech Biogen (2020). [link]
66. Toward in silico CMC: An industrial collaborative approach to model‐based process development, Biotech Biogen (2020). [link]
64. Physicochemical rules for identifying monoclonal antibodies with drug-like specificity, Mol Pharm (2020). [link]
64. Physicochemical rules for identifying monoclonal antibodies with drug-like specificity, Mol Pharm (2020). [link]
63. Directed evolution methods for overcoming trade-offs between protein activity and stability, AIChE Journal (special issue honoring Frances Arnold's Nobel Prize) (2020). [link]
63. Directed evolution methods for overcoming trade-offs between protein activity and stability, AIChE Journal (special issue honoring Frances Arnold's Nobel Prize) (2020). [link]
62. Unique impacts of methionine oxidation, tryptophan oxidation and asparagine deamidation on antibody stability and aggregation, J Pharm Sci (2020). [link]
62. Unique impacts of methionine oxidation, tryptophan oxidation and asparagine deamidation on antibody stability and aggregation, J Pharm Sci (2020). [link]
61. An engineered, pH-toggle switch, human Fc domain for ultra-long circulation persistence , Nat Commun (2019). [link]
61. An engineered, pH-toggle switch, human Fc domain for ultra-long circulation persistence , Nat Commun (2019). [link]
60. Sensitive detection of glucagon aggregation using amyloid fibril-specific antibodies, Biotech Bioeng, (2019). [link]
60. Sensitive detection of glucagon aggregation using amyloid fibril-specific antibodies, Biotech Bioeng, (2019). [link]
58. Deamidation compromises antibody colloidal stability and enhances aggregation in a pH-dependent manner, Mol Pharm (2019). [link]
58. Deamidation compromises antibody colloidal stability and enhances aggregation in a pH-dependent manner, Mol Pharm (2019). [link]
57. Selecting and engineering monoclonal antibodies with drug-like specificity, Current Opin Biotech (2019). [link]
57. Selecting and engineering monoclonal antibodies with drug-like specificity, Current Opin Biotech (2019). [link]
56. Net charge of the complementarity-determining regions is a key predictor of antibody specificity, Protein Eng Des Sel (2018). [link]
56. Net charge of the complementarity-determining regions is a key predictor of antibody specificity, Protein Eng Des Sel (2018). [link]
55. Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility, Biochem Eng J (2018). [link]
55. Understanding and overcoming trade-offs between antibody affinity, specificity, stability and solubility, Biochem Eng J (2018). [link]
54. Biophysical and sequence-based methods for identifying monovalent and bivalent antibodies with high colloidal stability, Mol Pharm (2018). [link]
54. Biophysical and sequence-based methods for identifying monovalent and bivalent antibodies with high colloidal stability, Mol Pharm (2018). [link]
53. Facile affinity maturation of antibody variable domains using natural diversity mutagenesis, Front Immunol (2017). [link]
53. Facile affinity maturation of antibody variable domains using natural diversity mutagenesis, Front Immunol (2017). [link]
52. Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs, J Biol Chem (2017). [link]
52. Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs, J Biol Chem (2017). [link]
51. Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability, Sci Rep (2017). [link]
51. Efficient affinity maturation of antibody variable domains requires co-selection of compensatory mutations to maintain thermodynamic stability, Sci Rep (2017). [link]
48. Facile preparation of stable antibody-gold conjugates and application to affinity-capture self-interaction nanoparticle spectroscopy, Bioconjug Chem (2016). [link]
48. Facile preparation of stable antibody-gold conjugates and application to affinity-capture self-interaction nanoparticle spectroscopy, Bioconjug Chem (2016). [link]
47. Measurements of monoclonal antibody self-association are correlated with complex biophysical properties, Mol Pharm (2016). [link]
47. Measurements of monoclonal antibody self-association are correlated with complex biophysical properties, Mol Pharm (2016). [link]
46. Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity, Biochim Biophys Acta (2016). [link]
46. Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity, Biochim Biophys Acta (2016). [link]
45. Design and optimization of anti-amyloid domain antibodies specific for Aβ and IAPP, J Biol Chem (2016). [link]
45. Design and optimization of anti-amyloid domain antibodies specific for Aβ and IAPP, J Biol Chem (2016). [link]
43. Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies, Protein Eng Des Sel (2015). [link]
43. Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies, Protein Eng Des Sel (2015). [link]
42. Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy, Protein Eng Des Sel (2015). [link]
42. Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy, Protein Eng Des Sel (2015). [link]
41. Comparison of human and bovine insulin amyloidogenesis under uniform shear, J Phys Chem B (2015). [link]
41. Comparison of human and bovine insulin amyloidogenesis under uniform shear, J Phys Chem B (2015). [link]
40. An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies, mAbs (2015). [link]
40. An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies, mAbs (2015). [link]
39. High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum, Bioconjug Chem (2015). [link]
39. High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum, Bioconjug Chem (2015). [link]
38. Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions, J Pharm Sci (2014). [link]
38. Improving monoclonal antibody selection and engineering using measurements of colloidal protein interactions, J Pharm Sci (2014). [link]
37. Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy, Biotech Bioeng (2014). [link]
37. Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy, Biotech Bioeng (2014). [link]
36. Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process, Expert Opin Drug Deliv (2014). [link]
36. Emerging methods for identifying monoclonal antibodies with low propensity to self-associate during the early discovery process, Expert Opin Drug Deliv (2014). [link]
35. Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold, Protein Eng Des Sel (2014). [link]
35. Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold, Protein Eng Des Sel (2014). [link]
34. High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy, mAbs (2014). [link]
34. High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy, mAbs (2014). [link]
32. Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones, Chem Biol (2013). [link]
32. Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones, Chem Biol (2013). [link]
29. Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates, Mol Pharm (2013). [link]
29. Rapid analysis of antibody self-association in complex mixtures using immunogold conjugates, Mol Pharm (2013). [link]
28. Rational design of potent domain antibody inhibitors of amyloid fibril assembly, P Natl Acad Sci U S A (2012). [link]
28. Rational design of potent domain antibody inhibitors of amyloid fibril assembly, P Natl Acad Sci U S A (2012). [link]
27. Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions, Protein Eng Des Sel (2012). [link]
27. Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions, Protein Eng Des Sel (2012). [link]
26. Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity, J Biol Chem (2012). [link]
26. Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity, J Biol Chem (2012). [link]
25. Polyphenolic disaccharides endow proteins with unusual resistance to aggregation, Biotech Bioeng (2012). [link]
25. Polyphenolic disaccharides endow proteins with unusual resistance to aggregation, Biotech Bioeng (2012). [link]
23. Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength, Mol Pharm (2012). [link]
23. Solution pH that minimizes self-association of three monoclonal antibodies is strongly dependent on ionic strength, Mol Pharm (2012). [link]
22. Structure-based design of conformation- and sequence-specific antibodies against amyloid β, P Natl Acad Sci U S A (2012). [link]
22. Structure-based design of conformation- and sequence-specific antibodies against amyloid β, P Natl Acad Sci U S A (2012). [link]
21. Removal versus fragmentation of amyloid-forming precursors via membrane filtration, Biotech Bioeng (2012). [link]
21. Removal versus fragmentation of amyloid-forming precursors via membrane filtration, Biotech Bioeng (2012). [link]
20. High-throughput analysis of concentration-dependent antibody self-association, Biophys J (2011). [link]
20. High-throughput analysis of concentration-dependent antibody self-association, Biophys J (2011). [link]
19. Site-specific structural analysis of a yeast prion strain with species-specific seeding activity, Prion (2011). [link]
19. Site-specific structural analysis of a yeast prion strain with species-specific seeding activity, Prion (2011). [link]
18. Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β, ChemBioChem (2011). [link]
18. Polyphenolic glycosides and aglycones utilize opposing pathways to selectively remodel and inactivate toxic oligomers of amyloid β, ChemBioChem (2011). [link]
17. Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions, Proteins (2011). [link]
17. Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions, Proteins (2011). [link]
16. Aromatic small molecules remodel toxic soluble oligomers of amyloid ß through three independent pathways, J Biol Chem (2011). [link]
16. Aromatic small molecules remodel toxic soluble oligomers of amyloid ß through three independent pathways, J Biol Chem (2011). [link]
15. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aß into off-pathway conformers, J Biol Chem (2010). [link]
15. Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aß into off-pathway conformers, J Biol Chem (2010). [link]
14. Unraveling molecular interactions and structures of self-perpetuating prions and amyloids, Nat Struct Mol Biol (2009). [link]
14. Unraveling molecular interactions and structures of self-perpetuating prions and amyloids, Nat Struct Mol Biol (2009). [link]
13. Biospecific immobilization of proteins for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy, Biotechnol Bioeng (2009). [link]
13. Biospecific immobilization of proteins for rapid analysis of weak protein interactions using self-interaction nanoparticle spectroscopy, Biotechnol Bioeng (2009). [link]
12. Self-interaction nanoparticle spectroscopy: A nanoparticle-based protein interaction assay, J Am Chem Soc (2008). [link]
12. Self-interaction nanoparticle spectroscopy: A nanoparticle-based protein interaction assay, J Am Chem Soc (2008). [link]
10. Direct measurement of protein osmotic second virial cross coefficients by cross-interaction chromatography, Protein Sci (2004). [link]
10. Direct measurement of protein osmotic second virial cross coefficients by cross-interaction chromatography, Protein Sci (2004). [link]
9. Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients, Proteins (2003). [link]
9. Predictive crystallization of ribonuclease A via rapid screening of osmotic second virial coefficients, Proteins (2003). [link]
8. Measurement of protein self-association as a guide to crystallization, Curr Opin Biotechnol (2003). [link]
8. Measurement of protein self-association as a guide to crystallization, Curr Opin Biotechnol (2003). [link]
7. Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross coefficients, Biotechol Bioeng (2003). [link]
7. Correlation of diafiltration sieving behavior of lysozyme-BSA mixtures with osmotic second virial cross coefficients, Biotechol Bioeng (2003). [link]
6. Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography, Biophys J (2002). [link]
6. Rapid measurement of protein osmotic second virial coefficients by self-interaction chromatography, Biophys J (2002). [link]
5. Self-interaction chromatography: A novel screening method for rational protein crystallization, Acta Cryst D (2002). [link]
5. Self-interaction chromatography: A novel screening method for rational protein crystallization, Acta Cryst D (2002). [link]
4. On-line spectroscopic characterization of sodium cyanide with nanostructured gold SERS substrates, Appl Spectrosc (2002). [link]
4. On-line spectroscopic characterization of sodium cyanide with nanostructured gold SERS substrates, Appl Spectrosc (2002). [link]
3. Structured metallic films for optical and spectroscopic applications via colloidal crystal templating, Adv Mater (2001). [link]
3. Structured metallic films for optical and spectroscopic applications via colloidal crystal templating, Adv Mater (2001). [link]
2. Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy, J Am Chem Soc (2000). [link]
2. Assembly of gold nanostructured films templated by colloidal crystals and use in surface-enhanced Raman spectroscopy, J Am Chem Soc (2000). [link]