Lab members

Craig Streu

Visiting Professor (Albion College)

Ph.D., Chemistry, University of Pennsylvania

B.A., Chemistry, Albion College

email: cstreu “@” albion.edu

Research interests: Drug discovery, directed evolution, biomolecular engineering, monoclonal antibodies, chemical methods for studying and modifying biological systems

Hongwei Chen

Research Laboratory Specialist

Ph.D., Polymer Science and Engineering, University of Science and Technology of China

M.S., Polymer Science and Engineering, Hefei University of Technology

B.S., Polymer Science and Engineering, Hefei University of Technology

email: hongweic “@” med.umich.edu

Research interests: Immunology, bionanotechnology, therapeutic discovery, protein engineering, polymer chemistry, biophysical characterization, drug-like antibody properties

John Schardt

NIH F32 Postdoctoral Fellow

Ph.D., Bioengineering, University of Maryland, College Park

B.S., Bioengineering, Lehigh University

email: jschardt “@” med.umich.edu

Research interests: Agonist antibodies, antibody discovery and engineering, functional screening for antibody discovery

Michael (Mike) Lucas

NIH T32 Postdoctoral Fellow

Ph.D. Chemical Engineering, University of Texas at Austin

M.S. Chemical Engineering, University of Texas at Austin

B.S., Chemical Engineering, University of Notre Dame

email: miclucas “@” med.umich.edu

Research interests: Conformational antibodies, neurodegenerative disease, targeted drug delivery, directed evolution, protein engineering

Jie Huang

Postdoctoral Fellow

Ph.D. Developmental Biology, Ocean University of China

B.S., Life Sciences, Ocean University of China

email: huangji “@” umich.edu

Research interests: Biomolecular engineering, protein therapeutics, drug-like antibody properties, protein engineering

Alec Desai

Doctoral Student (Chemical Engineering)

University of Michigan (2015-current)

B.S., Chemical Engineering - Institute of Chemical Technology

email: aldesai “@” umich.edu

Research interests: Antibody design and engineering, conformational antibodies, directed evolution, Alzheimer’s disease, tau, amyloid

Yulei Zhang

Doctoral Student (Chemical Engineering)

University of Michigan (2017-current)

M.S., University of Michigan, Ann Arbor

B.S., Rutgers University & Beijing University of Chemical Technology

email: yuleizh “@” umich.edu

Research interests: Prediction of drug-like properties of antibodies, antibody library design, bioinformatics analysis of antibody evolution, antibody specificity and affinity

Harkamal (Hark) Jhajj

Doctoral Student (Biomedical Engineering)

University of Michigan (2017-current)

B.S., University of Michigan, Dearborn

email: hjhajj “@” umich.edu

Research interests: agonist antibodies, antibody discovery, functional screens for agonist antibody discovery, protein engineering

Ghasidit (Meu) Pornnoppadol

Doctoral Student (Pharmaceutical Sciences)

University of Michigan (2017-current)

M.S., Korea Advanced Institute of Science and Technology (KAIST), South Korea

B.E., Chulalongkorn University, Thailand

email: ghasidit “@” umich.edu

Research interests: antibody discovery, conformational antibodies, Alzheimer’s disease, tauopathies, therapeutics, physicochemical analysis of monoclonal antibodies

Matthew Smith

Doctoral Student (Chemical Engineering)

NSF Graduate Research Fellow (2019-2022)

University of Michigan (2018-current)

B.S., Chemical Engineering, Michigan State

email: mduncans “@” umich.edu

Research interests: antibody discovery, antibody library design, next-generation sequencing, computational antibody design, conformational antibodies, functional screens for antibody discovery

Jennifer Zupancic

Doctoral Student (Chemical Engineering)

University of Michigan (2018-current)

B.S., Bioengineering and Chemistry, University of Illinois, Urbana-Champaign

email: jenzup “@” umich.edu

Research interests: antibody discovery, conformational antibodies, Alzheimer’s disease, tauopathies, therapeutics, physicochemical analysis of monoclonal antibodies

Emily Makowski

Doctoral student (Pharmaceutical Sciences)

University of Michigan (2018-current)

B.S., Chemistry, The Ohio State University

email: emilymak “@” med.umich.edu

Research interests: antibody stability, protein engineering, bioinformatics, prediction of drug-like antibody properties

Neelan Sivaneri

Doctoral Student (Chemical Engineering)

University of Michigan (2020-current)

B.S., Chemical Engineering, Rutgers

email: neelans “@” umich.edu

Research interests: antibody engineering, directed evolution, antibody brain targeting, co-optimization of antibody affinity and specificity

Tiexin Wang

Doctoral Student (Chemical Engineering)

University of Michigan (2020-current)

M.S., Chemical & Biomolecular Engineering, Johns Hopkins University

B.S., Pharmaceutical Engineering, Tianjin Univerisity

email: txwang “@” umich.edu

Research interests: cancer therapeutics, antibody-drug conjugates, protein engineering

Hsin-Ting Chen

Doctoral Student (Chemical Engineering)

University of Michigan (2020-current)

B.S., Chemical Engineering, National Tsing Hua University, Taiwan

email: htdennis “@” umich.edu

Research interests: machine learning, computational modeling, prediction of antibody affinity and specificity, antibody engineering

Layne Bond

Doctoral Student (Chemical Biology), co-advised by Dr. Colin Greineder

University of Michigan (2020-current)

M.S., Chemical Biology of Cancer, University of Michigan

B.S., Neuroscience, University of Michigan

email: lgbond “@” umich.edu

Research interests: neuroscience, targeted drug delivery, neurodegeneration, therapeutic antibodies, blood brain barrier

Murat Karadag

Visiting Doctoral Student

University of Michigan (2021-current)

Molecular Biology and Genetics, Izmir Biomedicine and Genome Center, Turkey (2018-current)

M.S., Biochemistry, Izmir Biomedicine and Genome Center, Turkey

B.S., Biochemistry, Izmir Biomedicine and Genome Center, Turkey

email: muratkar “@” umich.edu

Research interests: antibody engineering, protein stability, aggregation-resistant antibodies, directed evolution, cancer imaging and therapeutics